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Literature summary for 3.4.24.11 extracted from

  • Guan, H.; Liu, Y.; Daily, A.; Police, S.; Kim, M.H.; Oddo, S.; LaFerla, F.M.; Pauly, J.R.; Murphy, M.P.; Hersh, L.B.
    Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease (2009), J. Neurosci. Res., 87, 1462-1473.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine expression of neprilysin on the surface of leukocytes in mouse model of Alzheimer's disease reduces soluble brain amyloid beta peptide levels by 30% and lowers the accumulation of amyloid beta peptides by 50-60% when transplantation is performed at both young and early adult age. Peripheral neprilysin expression reduces amyloid-dependent performance deficits as measured by the Morris water maze test. Neprilysin expression results in the catabolism of amyloid beta to small, innocuous peptide fragments Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in 3xTg-AD mice containing, in addition to a PS1M146V knock-in gene, a human APP695 gene carrying the Swedish double mutation and a human four-repeat tau harboring the P30lL mutation Homo sapiens

Protein Variants

Protein Variants Comment Organism
E585V inactive Homo sapiens
additional information expression of neprilysin on the surface of leukocytes in mouse model of Alzheimer's disease reduces soluble brain amyloid beta peptide levels by 30% and lowers the accumulation of amyloid beta peptides by 50-60% when transplantation is performed at both young and early adult age. Peripheral neprilysin expression reduces amyloid-dependent performance deficits as measured by the Morris water maze test. Neprilysin expression results in the catabolism of amyloid beta to small, innocuous peptide fragments Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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