Application | Comment | Organism |
---|---|---|
diagnostics | napsin A is a reliable marker for pulmonary adenocarcinoma and is expressed in a subset of ovarian clear cell carcinomas (O-CCCs), endometrial (EM) CCCs, and endometrioid carcinomas (EC). Napsin A levels in O-CCC and EM-CCC are analyzed and compared with levels in other nonmucinous ovarian carcinomas and EM-EC, respectively. But for diagnostics of napsin A expression in Arias-Stella reactions, napsin A expression is frequently present in foci of Arias-Stella reaction, a feature that they share with clear cell carcinomas. Therefore, Napsin A, in and of itself, is of minimal utility in this specific differential diagnostic scenario | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
enzyme expression analysis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
additional information | foci of Arias-Stella reaction are napsin A positive, expression analysis | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O96009 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endometrial clear cell carcinoma cell | - |
Homo sapiens | - |
additional information | in the endometrium, one lesion in the differential diagnosis of clear cell carcinoma is the nonneoplastic, progestin-related alteration, Arias-Stella reaction. Napsin A is frequently expressed in ovarian clear cell carcinomas (O-CCCs) and endometrial (EM) CCCs, but rarely in ovarian carcinomas (O-EC) and endometrioid carcinomas (EM-EC), and never in high-grade serous carcinoma [HGSC] cases | Homo sapiens | - |
ovarian clear cell carcinoma cell | - |
Homo sapiens | - |
uterine endometrium | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
napsin A | - |
Homo sapiens |