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Literature summary for 3.4.23.5 extracted from

  • Xu, H.; Bao, K.; Tang, S.; Ai, J.; Hu, H.; Zhang, W.
    Cyanobacterial peptides as a prototype for the design of cathepsin D inhibitors (2017), J. Pept. Sci., 23, 701-706 .
    View publication on PubMed
Search for more literature for 3.4.23.5

Inhibitors

Inhibitors Comment Organism Structure
(3S,4S)-4-(2-[4-[4-amino-3-(4-chlorophenyl)butanoyl]-1-[([1,1'-biphenyl]-4-yl)methyl]piperazin-2-yl]acetamido)-N-butyl-3-hydroxy-5-phenylpentanamide
-
 Homo sapiens
(3S,4S)-N-butyl-3-hydroxy-5-phenyl-4-[2-(4-[4-[(propan-2-yl)oxy]benzoyl]-1-[(3,4,5-trimethoxyphenyl)methyl]piperazin-2-yl)acetamido]pentanamide
-
 Homo sapiens
ethyl 6-(2-[[(2S,3S)-5-(butylamino)-3-hydroxy-5-oxo-1-phenylpentan-2-yl]carbamoyl]-4-[3-(3,4,5-trimethoxyphenyl)propanoyl]piperazin-1-yl)-6-oxohexanoate
-
 Homo sapiens
methyl (2S)-1-[(2R,5S,8S,12S,13S)-2,13-dibenzyl-12-hydroxy-15-(3-[(methanesulfonyl)(methyl)amino]-5-[[(1R)-1-phenylethyl]carbamoyl]phenyl)-3,5-dimethyl-8-(2-methylpropyl)-4,7,10,15-tetraoxo-3,6,9,14-tetraazapentadecanan-1-oyl]pyrrolidine-2-carboxylate
-
 Homo sapiens
additional information not inhibited by paclitaxel Homo sapiens
N-[(2S,3S)-5-(butylamino)-3-hydroxy-5-oxo-1-phenylpentan-2-yl]-1-[2-(2-phenylethoxy)ethyl]-4-[3-(3,4,5-trimethoxyphenyl)propanoyl]piperazine-2-carboxamide
-
 Homo sapiens
N1-[(2S,3S)-3-hydroxy-5-([(2S)-4-methyl-1-[(2-methylpropyl)amino]-1-oxopentan-2-yl]amino)-5-oxo-1-phenylpentan-2-yl]-5-[(methanesulfonyl)(methyl)amino]-N3-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
-
 Homo sapiens
N1-[(2S,3S)-3-hydroxy-5-[[(2S)-1-[[(3-methoxyphenyl)methyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxo-1-phenylpentan-2-yl]-5-[(methanesulfonyl)(methyl)amino]-N3-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
-
 Homo sapiens
N1-[(2S,3S)-5-[[(2S)-1-(cyclopropylamino)-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-5-oxo-1-phenylpentan-2-yl]-5-[(methanesulfonyl)(methyl)amino]-N3-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
-
 Homo sapiens
pepstatin A
-
 Homo sapiens
tasiamide B
-
 Homo sapiens
TB-13
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Cath D
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000059
-
 pH and temperature not specified in the publication Homo sapiens pepstatin A
0.00000584
-
 pH and temperature not specified in the publication Homo sapiens TB-13
0.00000584
-
 i.e. TB-13, pH and temperature not specified in the publication Homo sapiens methyl (2S)-1-[(2R,5S,8S,12S,13S)-2,13-dibenzyl-12-hydroxy-15-(3-[(methanesulfonyl)(methyl)amino]-5-[[(1R)-1-phenylethyl]carbamoyl]phenyl)-3,5-dimethyl-8-(2-methylpropyl)-4,7,10,15-tetraoxo-3,6,9,14-tetraazapentadecanan-1-oyl]pyrrolidine-2-carboxylate
0.000015
-
 pH and temperature not specified in the publication Homo sapiens N1-[(2S,3S)-3-hydroxy-5-([(2S)-4-methyl-1-[(2-methylpropyl)amino]-1-oxopentan-2-yl]amino)-5-oxo-1-phenylpentan-2-yl]-5-[(methanesulfonyl)(methyl)amino]-N3-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
0.000353
-
 pH and temperature not specified in the publication Homo sapiens N1-[(2S,3S)-3-hydroxy-5-[[(2S)-1-[[(3-methoxyphenyl)methyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxo-1-phenylpentan-2-yl]-5-[(methanesulfonyl)(methyl)amino]-N3-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
0.000884
-
 pH and temperature not specified in the publication Homo sapiens N1-[(2S,3S)-5-[[(2S)-1-(cyclopropylamino)-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-5-oxo-1-phenylpentan-2-yl]-5-[(methanesulfonyl)(methyl)amino]-N3-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide