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Literature summary for 3.4.23.46 extracted from

  • Zhou, P.; Li, Y.; Fan, Y.; Wang, Z.; Chopra, R.; Olland, A.; Hu, Y.; Magolda, R.L.; Pangalos, M.; Reinhart, P.H.; Turner, M.J.; Bard, J.; Malamas, M.S.; Robichaud, A.J.
    Pyridinyl aminohydantoins as small molecule BACE1 inhibitors (2010), Bioorg. Med. Chem. Lett., 20, 2326-2329.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(5S)-2-amino-5-(2',4'-difluorobiphenyl-3-yl)-3-methyl-5-(pyridin-4-yl)-3,5-dihydro-4H-imidazol-4-one 5fold selectivity for BACE2 over BACE1, 27fold selectivity for BACE2 over cathepsin D Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00002
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens (5S)-2-amino-5-(2',4'-difluorobiphenyl-3-yl)-3-methyl-5-(pyridin-4-yl)-3,5-dihydro-4H-imidazol-4-one