Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid-beta precursor protein + H2O | Rattus norvegicus | - |
amyloid-beta protein 40 + amyloid-beta protein 42 | - |
? | |
CD44 + H2O | Rattus norvegicus | - |
? | - |
? | |
E-cadherin + H2O | Rattus norvegicus | - |
? | - |
? | |
ErbB4 + H2O | Rattus norvegicus | - |
? | - |
? | |
Notch-1 + H2O | Rattus norvegicus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
spinal cord | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid-beta precursor protein + H2O | - |
Rattus norvegicus | amyloid-beta protein 40 + amyloid-beta protein 42 | - |
? | |
CD44 + H2O | - |
Rattus norvegicus | ? | - |
? | |
E-cadherin + H2O | - |
Rattus norvegicus | ? | - |
? | |
ErbB4 + H2O | - |
Rattus norvegicus | ? | - |
? | |
Notch-1 + H2O | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gamma-secretase | gamma-secretase is composed of four proteins: presenilin, nicastrin, aph1, and pen2 | Rattus norvegicus |
presenilin 1 | catalytic subunit ofgamma-secretase | Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | induced expression of PS1 represents induction of gamma-secretase activity in injured white matter axons | up |
General Information | Comment | Organism |
---|---|---|
physiological function | gamma-secretase (regulated intramembrane proteolysis signaling) plays an important role in the restoration or collapse of axons in the white matter after hemisection of the spinal cord | Rattus norvegicus |