Activating Compound | Comment | Organism | Structure |
---|---|---|---|
bovine lung heparin | 0.0001 mg/ml increases BACE1 activity by 1600% | Homo sapiens | |
heparan sulfate | 0.0001 mg/ml increases BACE1 activity by 900% | Homo sapiens | |
heparin | heparin can increase the enzyme activity of the partially active zymogen proBACE1 | Homo sapiens | |
additional information | heparin disaccharide does not stimulate proBACE1 activity at a concentration of 0.00001-0.1 mg/ml | Homo sapiens | |
mucosal heparin | 0.0001 mg/ml increases BACE1 activity by 900%, heparin tetrasaccharide inhibits stimulation of proBACE1 by full-length mucosal heparin at concentrations of greater than 0.0005 mg/ml | Homo sapiens | |
poly-D-glutamic acid | 0.0001 mg/ml increases BACE1 activity by 170% | Homo sapiens | |
polysialic acid | 0.0001 mg/ml increases BACE1 activity by 160% | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | Homo sapiens | - |
fragments of amyloid precursor protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P56817 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | - |
Homo sapiens | fragments of amyloid precursor protein | - |
? | |
Mca-SEVNLDAEFRK(2,4-dinitrophenyl)RR-NH2 + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Homo sapiens |
beta-secretase | - |
Homo sapiens |
beta-site APP cleaving enzyme | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | BACE1 is responsible for the first step in the production of the beta-amyloid protein of Alzheimer's disease | Homo sapiens |