Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | upon exposure to various cell stressors including amyloid-beta 1-42, expression of BACE1-antisense transcript becomes elevated leading to increased BACE1 mRNA stability. BACE1 expression by BACE1-antisense transcript does not occur only at the mRNA but also at the protein level. BACE1 mRNA expression is under the control of a regulatory noncoding RNA that may drive Alzheimer's disease-associated pathophysiology. | Mus musculus | |
additional information | upon exposure to various cell stressors including amyloid-beta 1-42, expression of BACE1-antisense transcript becomes elevated leading to increased BACE1 mRNA stability. BACE1 expression by BACE1-antisense transcript does not occur only at the mRNA but also at the protein level. BACE1 mRNA expression is under the control of a regulatory noncoding RNA that may drive Alzheimer's disease-associated pathophysiology. | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | the BACE1-antisense transcript regulates BACE1 mRNA and subsequently BACE1 protein expression in vitro and in vivo. Upon exposure to various cell stressors including amyloid-beta 1-42 , expression of BACE1-antisense becomes elevated, increasing BACE1 mRNA stability and generating additional amyloid beta 1-42 through a post-transcriptional feed-forward mechanism. BACE1-antisense concentrations are elevated in subjects with Alzheimer's disease | Homo sapiens |
medicine | the BACE1-antisense transcript regulates BACE1 mRNA and subsequently BACE1 protein expression in vitro and in vivo. Upon exposure to various cell stressors including amyloid-beta 1-42 , expression of BACE1-antisense becomes elevated, increasing BACE1 mRNA stability and generating additional amyloid beta 142 through a post-transcriptional feed-forward mechanism. BACE1-antisense concentrations are elevated in amyloid precursor protein transgenic mice | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expressed in HEK-293T cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the BACE1-antisense transcript regulates BACE1 mRNA and subsequently BACE1 protein expression in vitro and in vivo. Upon exposure to various cell stressors including amyloid-beta 1-42 , expression of BACE1-antisense becomes elevated, increasing BACE1 mRNA stability and generating additional amyloid beta 1-42 through a post-transcriptional feed-forward mechanism. BACE1-antisense concentrations are elevated in subjects with Alzheimer's disease | Homo sapiens |
additional information | the BACE1-antisense transcript regulates BACE1 mRNA and subsequently BACE1 protein expression in vitro and in vivo. Upon exposure to various cell stressors including amyloid-beta 1-42 , expression of BACE1-antisense becomes elevated, increasing BACE1 mRNA stability and generating additional amyloid beta 142 through a post-transcriptional feed-forward mechanism. BACE1-antisense concentrations are elevated in amyloid precursor protein transgenic mice | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebellum | - |
Homo sapiens | - |
cerebral cortical neuron | - |
Mus musculus | - |
cerebral cortical neuron | - |
Homo sapiens | - |
neuron | - |
Mus musculus | - |
neuron | - |
Homo sapiens | - |
parietal lobe | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Mus musculus |
BACE1 | - |
Homo sapiens |
beta-secretase-1 | - |
Mus musculus |
beta-secretase-1 | - |
Homo sapiens |