Application | Comment | Organism |
---|---|---|
medicine | cholesterol depletion within the cellular context inhibits both beta-secretase and gamma-secretase additively and independently from each other. The parallel and additive inhibition may indicate an intrinsic cross-talk between Alzheimer disease-related amyloid precursor protein processing, amyloid precursor protein function, and lipid biology | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | cholesterol depletion within the cellular context inhibits both beta-secretase and gamma-secretase additively and independently from each other. The parallel and additive inhibition may indicate an intrinsic cross-talk between Alzheimer disease-related amyloid precursor protein processing, amyloid precursor protein function, and lipid biology; cyclodextrin does not affect the protein levels of BACE I | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SH-SY5Y cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
BACE I | - |
Homo sapiens |
beta-secretase | - |
Homo sapiens |