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Literature summary for 3.4.23.45 extracted from

  • Wang, Z.; Xu, Q.; Cai, F.; Liu, X.; Wu, Y.; Song, W.
    BACE2, a conditional beta-secretase, contributes to Alzheimer's disease pathogenesis (2019), JCI Insight, 4, e123431 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.45

Inhibitors

Inhibitors Comment Organism Structure
additional information the juxtamembrane helix of amyloid precursor protein is crucial to inhibit the beta-secretase activity of the enzyme Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor protein + H2O Mus musculus the enzyme cleaves amyloid precursor protein within the Abeta domain, particularly at the zeta-site (Phe20) to produce fragment C80 and prevents Abeta generation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9JL18
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex
-
 Mus musculus
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cerebral cortical neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O the enzyme cleaves amyloid precursor protein within the Abeta domain, particularly at the zeta-site (Phe20) to produce fragment C80 and prevents Abeta generation Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
BACE2
-
 Mus musculus
beta-site APP cleaving enzyme 2
-
 Mus musculus

General Information

General Information Comment Organism
metabolism enzyme-mediated beta-cleavage of amyloid precursor protein is a mechanism underlying Alzheimer's disease pathogenesis Mus musculus