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Literature summary for 3.4.23.38 extracted from
- Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase (1994), EMBO J., 13, 306-317.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Plasmodium falciparum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | inhibition of the enzyme blocks the essential pathway of hemoglobin degradation, leading to death of the organism | Plasmodium falciparum |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| vacuole | digestive vacuole | Plasmodium falciparum | 5773 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Hemoglobin + H2O | Plasmodium falciparum | the enzyme initiates the hemoglobin degradation pathway in Plasmodium | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium falciparum | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Hemoglobin + H2O | the enzyme initiates the hemoglobin degradation pathway in Plasmodium | Plasmodium falciparum | ? | - |
? | |
| hemoglobin alpha-chain + H2O | - |
Plasmodium falciparum | ? | - |
? | |
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