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Literature summary for 3.4.23.2 extracted from

  • Ryle, A.P.
    Pepsinogen B: the zymogen of pepsin B (1965), Biochem. J., 95, 6-16.
No PubMed abstract available
Search for more literature for 3.4.23.2

Activating Compound

Activating Compound Comment Organism Structure
additional information activation of pepsinogen B to pepsin B rapidly at pH 2, more slowly at pH 4, pepsinogen B contains 1 mol phosphate per mol enzyme, function unclear Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
57200
-
 pepsinogen B, gel filtration, 57200 Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Proteins + H2O Sus scrofa enzyme formed from pepsinogen B, more restricted specificity than pepsin A ?
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification
-
 Sus scrofa

Purification (Commentary)

Purification (Comment) Organism
pepsinogen B Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
gastric mucosa
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 with pepsinogen B Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-Phe-L-diiodotyrosine + H2O
-
 Sus scrofa acetyl-L-phenylalanine + L-diiodotyrosine
-
 ir
gelatin + H2O
-
 Sus scrofa ? + ?
-
 ir
additional information little if any activity with hemoglobin Sus scrofa ?
-
 ?
proteins + H2O gelatin Sus scrofa acetyl-L-phenylalanyl-L-diiodotyrosine + H2O
-
 ir
proteins + H2O more restricted specificity than pepsin A Sus scrofa acetyl-L-phenylalanyl-L-diiodotyrosine + H2O
-
 ir
proteins + H2O little activity with hemoglobin Sus scrofa acetyl-L-phenylalanyl-L-diiodotyrosine + H2O
-
 ir
Proteins + H2O enzyme formed from pepsinogen B, more restricted specificity than pepsin A Sus scrofa ?
-
 ?

Subunits

Subunits Comment Organism
? N-terminal amino acid sequence reported Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35.5
-
 assay at Sus scrofa