Protein Variants | Comment | Organism |
---|---|---|
D29N | the mutation can largely reduce the binding capability of the two peptides ARVLAEAM and NLAFPQGE as compared to the wild type enzyme | Human immunodeficiency virus 1 |
I54V | the mutant enzyme is resistant against inhibition by darunavir and nelfinavir | Human immunodeficiency virus 1 |
L10I | the mutant enzyme is resistant against inhibition by darunavir and tipranavir | Human immunodeficiency virus 1 |
L90M | the mutant enzyme is resistant against inhibition by darunavir and tipranavir | Human immunodeficiency virus 1 |
M46L | the mutant enzyme is resistant against inhibition by darunavir and saquinavir | Human immunodeficiency virus 1 |
N25D | the mutation completely eliminates the binding capability of the two peptides ARVLAEAM and NLAFPQGE as compared to the wild type enzyme | Human immunodeficiency virus 1 |
V82T | the mutant enzyme is resistant against inhibition by darunavir | Human immunodeficiency virus 1 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
atazanavir | - |
Human immunodeficiency virus 1 | |
darunavir | - |
Human immunodeficiency virus 1 | |
fosamprenavir | - |
Human immunodeficiency virus 1 | |
indinavir | - |
Human immunodeficiency virus 1 | |
lopinavir | - |
Human immunodeficiency virus 1 | |
nelfinavir | - |
Human immunodeficiency virus 1 | |
saquinavir | - |
Human immunodeficiency virus 1 | |
tipranavir | - |
Human immunodeficiency virus 1 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gag polyprotein + H2O | Human immunodeficiency virus 1 | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | Q7SSI0 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
AETFYVDG + H2O | - |
Human immunodeficiency virus 1 | AETF + YVDG | - |
? | |
ARVLAEAM + H2O | - |
Human immunodeficiency virus 1 | ARVL + AEAM | - |
? | |
ATIMMQRG + H2O | - |
Human immunodeficiency virus 1 | ATIM + MQRG | - |
? | |
DCAWLEAQ + H2O | - |
Human immunodeficiency virus 1 | DCAW + LEAQ | - |
? | |
Gag polyprotein + H2O | - |
Human immunodeficiency virus 1 | ? | - |
? | |
NLAFPQGE + H2O | - |
Human immunodeficiency virus 1 | NLAF + PQG | - |
? | |
PGNFLQSR + H2O | - |
Human immunodeficiency virus 1 | PGNF + LQSR | - |
? | |
RKVLFLDG + H2O | - |
Human immunodeficiency virus 1 | RKVL + FLDG | - |
? | |
RQANFLGK + H2O | - |
Human immunodeficiency virus 1 | RQAN + FLGK | - |
? | |
RQANFLRE + H2O | - |
Human immunodeficiency virus 1 | RQAN + FLRE | - |
? | |
SQNYPIVQ + H2O | - |
Human immunodeficiency virus 1 | SQNY + PIVQ | - |
? | |
TLNFPISP + H2O | - |
Human immunodeficiency virus 1 | TLNF + PISP | - |
? | |
TLNFPQIT + H2O | - |
Human immunodeficiency virus 1 | TLNF + PQIT | - |
? | |
TNIMMQKS + H2O | - |
Human immunodeficiency virus 1 | TNIM + MQKS | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HIV-1 PR | - |
Human immunodeficiency virus 1 |
HIV-1 protease | - |
Human immunodeficiency virus 1 |