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Literature summary for 3.4.23.16 extracted from

  • Laco, G.S.
    HIV-1 protease substrate-groove Role in substrate recognition and inhibitor resistance (2015), Biochimie, 118, 90-103 .
    View publication on PubMed
Search for more literature for 3.4.23.16

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 pLysY/Iq cells Human immunodeficiency virus 1

Protein Variants

Protein Variants Comment Organism
D30N inhibitor nelfinavir-resistant mutant Human immunodeficiency virus 1
D30N/N88D inhibitor nelfinavir-resistant mutant Human immunodeficiency virus 1
I50V/G73S/I84V inhibitor amprenavir-resistant mutant Human immunodeficiency virus 1
I50V/I84V inhibitor amprenavir-resistant mutant Human immunodeficiency virus 1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gag polyprotein + H2O Human immunodeficiency virus 1 Gag polyprotein with cleavage-site P12-P5/P5'-P12' residues matrix-capsid polyprotein + ?
-
 ?
matrix-capsid polyprotein + H2O Human immunodeficiency virus 1 i.e. DTGNNSQVSQNYPIVQNLQGQMVH DTGNNSQVSQNY + PIVQNLQGQMVH
-
 ?

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1 Q5RZ08
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-KDKTK-Abz-VLF-NO2-VQPKK-NH2 + H2O
-
 Human immunodeficiency virus 1 acetyl-KDKTK-Abz-VL + F-NO2-VQPKK-NH2
-
 ?
Gag polyprotein + H2O Gag polyprotein with cleavage-site P12-P5/P5'-P12' residues Human immunodeficiency virus 1 matrix-capsid polyprotein + ?
-
 ?
matrix-capsid polyprotein + H2O i.e. DTGNNSQVSQNYPIVQNLQGQMVH Human immunodeficiency virus 1 DTGNNSQVSQNY + PIVQNLQGQMVH
-
 ?

Synonyms

Synonyms Comment Organism
HIV-1 PR
-
 Human immunodeficiency virus 1
HIV-1 protease
-
 Human immunodeficiency virus 1