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Literature summary for 3.4.23.1 extracted from

  • Kageyama, H.; Ueda, H.; Tezuka, T.; Ogasawara, A.; Narita, Y.; Kageyama, T.; Ichinose, M.
    Differences in the P1' substrate specificities of pepsin A and chymosin (2010), J. Biochem., 147, 167-174.
    View publication on PubMed
Search for more literature for 3.4.23.1

Inhibitors

Inhibitors Comment Organism Structure
pepstatin A
-
 Homo sapiens
pepstatin A
-
 Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.022
-
 POMC (165-174) in 0.2 M sodium formate buffer, pH 4.0, at 37°C Sus scrofa
0.029
-
 POMC (165-174) in 0.2 M sodium formate buffer, pH 4.0, at 37°C Homo sapiens
0.079
-
 AFPLEFIREL in 0.2 M sodium formate buffer, pH 4.0, at 37°C Homo sapiens
0.084
-
 AFPLEFFREL in 0.2 M sodium formate buffer, pH 4.0, at 37°C Homo sapiens
0.098
-
 AFPLEFIREL in 0.2 M sodium formate buffer, pH 4.0, at 37°C Sus scrofa
0.17
-
 AFPLEFFREL in 0.2 M sodium formate buffer, pH 4.0, at 37°C Sus scrofa
0.3
-
 AFPLEFEREL in 0.2 M sodium formate buffer, pH 4.0, at 37°C Homo sapiens
0.4
-
 AFPLEFEREL in 0.2 M sodium formate buffer, pH 4.0, at 37°C Sus scrofa

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
AFPLEFEREL + H2O
-
 Homo sapiens AFPLEF + EREL
-
 ?
AFPLEFEREL + H2O
-
 Sus scrofa AFPLEF + EREL
-
 ?
AFPLEFFREL + H2O
-
 Homo sapiens AFPLEF + FREL
-
 ?
AFPLEFFREL + H2O
-
 Sus scrofa AFPLEF + FREL
-
 ?
AFPLEFIREL + H2O
-
 Homo sapiens AFPLEF + IREL
-
 ?
AFPLEFIREL + H2O
-
 Sus scrofa AFPLEF + IREL
-
 ?
dynorphin A (1-7) + H2O
-
 Homo sapiens ?
-
 ?
dynorphin A (1-7) + H2O
-
 Sus scrofa ?
-
 ?
Hemoglobin + H2O
-
 Homo sapiens ?
-
 ?
Hemoglobin + H2O
-
 Sus scrofa ?
-
 ?
HPHLSFMAI + H2O best substrate Homo sapiens HPHLSF + Met-Ala-Ile + ?
-
 ?
HPHLSFMAI + H2O best substrate Sus scrofa HPHLSF + Met-Ala-Ile + ?
-
 ?
KPAEFFRL + H2O
-
 Homo sapiens KPAEF + FRL
-
 ?
KPAEFFRL + H2O
-
 Sus scrofa KPAEF + FRL
-
 ?
KYSSWYVAL + H2O
-
 Homo sapiens KYSSW + YVAL
-
 ?
KYSSWYVAL + H2O
-
 Sus scrofa KYSSW + YVAL
-
 ?
additional information pepsin A strongly prefers a hydrophobic/aromatic residue at P1’ in any type of peptide Homo sapiens ?
-
 ?
additional information pepsin A strongly prefers a hydrophobic/aromatic residue at P1’ in any type of peptide Sus scrofa ?
-
 ?
NT/NMN (142-151) + H2O
-
 Homo sapiens KIPYIL + KRQL
-
 ?
NT/NMN (142-151) + H2O
-
 Sus scrofa KIPYIL + KRQL
-
 ?
POMC (165-174) + H2O
-
 Homo sapiens AFPLE + FKREL
-
 ?
POMC (165-174) + H2O
-
 Sus scrofa AFPLE + FKREL
-
 ?
substance P + H2O
-
 Homo sapiens RPKPQQF + FGLM
-
 ?
substance P + H2O
-
 Sus scrofa RPKPQQF + FGLM
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7
-
 POMC (165-174) in 0.2 M sodium formate buffer, pH 4.0, at 37°C Homo sapiens
3.7
-
 POMC (165-174) in 0.2 M sodium formate buffer, pH 4.0, at 37°C Sus scrofa
8.9
-
 AFPLEFEREL in 0.2 M sodium formate buffer, pH 4.0, at 37°C Homo sapiens
45
-
 AFPLEFEREL in 0.2 M sodium formate buffer, pH 4.0, at 37°C Sus scrofa
56
-
 AFPLEFIREL in 0.2 M sodium formate buffer, pH 4.0, at 37°C Homo sapiens
85
-
 AFPLEFFREL in 0.2 M sodium formate buffer, pH 4.0, at 37°C Homo sapiens
203
-
 AFPLEFIREL in 0.2 M sodium formate buffer, pH 4.0, at 37°C Sus scrofa
472
-
 AFPLEFFREL in 0.2 M sodium formate buffer, pH 4.0, at 37°C Sus scrofa

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
29
-
 AFPLEFEREL in 0.2 M sodium formate buffer, pH 4.0, at 37°C Homo sapiens
93
-
 POMC (165-174) in 0.2 M sodium formate buffer, pH 4.0, at 37°C Homo sapiens
110
-
 AFPLEFEREL in 0.2 M sodium formate buffer, pH 4.0, at 37°C Sus scrofa
170
-
 POMC (165-174) in 0.2 M sodium formate buffer, pH 4.0, at 37°C Sus scrofa
730
-
 AFPLEFIREL in 0.2 M sodium formate buffer, pH 4.0, at 37°C Homo sapiens
1000
-
 AFPLEFFREL in 0.2 M sodium formate buffer, pH 4.0, at 37°C Homo sapiens
2100
-
 AFPLEFIREL in 0.2 M sodium formate buffer, pH 4.0, at 37°C Sus scrofa
2800
-
 AFPLEFFREL in 0.2 M sodium formate buffer, pH 4.0, at 37°C Sus scrofa