Literature summary for 3.4.22.B79 extracted from

Compton, J.R.; Mickey, M.J.; Hu, X.; Marugan, J.J.; Legler, P.M.
Mutation of Asn-475 in the Venezuelan equine encephalitis virus nsP2 cysteine protease leads to a self-inhibited state (2017), Biochemistry, 56, 6221-6230 .

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Venezuelan equine encephalitis virus

Crystallization (Commentary)

Crystallization (Comment)	Organism
structure of mutant N475A	Venezuelan equine encephalitis virus

Protein Variants

Protein Variants	Comment	Organism
N475A	mutation of a conserved motif residue, produces a self-inhibited state in which the N-terminal residues flipp into the substrate-binding cleft. Mutation results in a 70fold decrease in kcat/Km	Venezuelan equine encephalitis virus
S701A	mutation leads to a 17fold increase in Km	Venezuelan equine encephalitis virus

Organism

Organism	UniProt	Comment	Textmining
Venezuelan equine encephalitis virus	P27282	polyprotein	-
Venezuelan equine encephalitis virus Trinidad donkey	P27282	polyprotein	-

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Release 2023.1 (January 2023)