Cloned (Comment) | Organism |
---|---|
recombinant expression of N-terminally FLAG-tagged wild-type and mutant enzymes in HEK-293 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C992A | site-directed mutagenesis, inactive catalytic mutant | Homo sapiens |
additional information | enzyme knockout by siRNA in HeLa cells, complementation of knockdown with siRNA-resistant Flag-SENP7 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme SENP7 interacts with the chromatin repressive KRAB-associated protein 1 through heterochromatin protein 1 alpha, HP1alapha. Enzyme SENP7 contains a conserved HP1-box, PxVxL, required for interaction with HP1 | ? | - |
? | |
SUMOylated KRAB-associated protein 1 + H2O | Homo sapiens | enzyme SENP7 promotes the removal of SUMO2/3 from KRAB-associated protein 1 | KRAB-associated protein 1 + SUMO 2 + SUMO3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme SENP7 interacts with the chromatin repressive KRAB-associated protein 1 through heterochromatin protein 1 alpha, HP1alapha. Enzyme SENP7 contains a conserved HP1-box, PxVxL, required for interaction with HP1 | Homo sapiens | ? | - |
? | |
polySUMO2 KRAB-associated protein 1 + H2O | enzyme SENP7 promotes the removal of SUMO2 from KRAB-associated protein 1 | Homo sapiens | KRAB-associated protein 1 + SUMO 2 + SUMO3 | - |
? | |
SUMOylated KRAB-associated protein 1 + H2O | enzyme SENP7 promotes the removal of SUMO2/3 from KRAB-associated protein 1 | Homo sapiens | KRAB-associated protein 1 + SUMO 2 + SUMO3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SENP7 | - |
Homo sapiens |
SUMO/sentrin/Smt3-specific peptidase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | homologous recombination is affected in SENP7 knockout cells | Homo sapiens |
metabolism | DNA damage-associated remodelling requires SENP7, overview | Homo sapiens |
physiological function | enzyme SENP7 promotes the removal of SUMO2/3 from KRAB-associated protein 1 and regulates the interaction of the chromatin remodeler CHD3 with chromatin. In the presence of CHD3, SENP7 is required for chromatin relaxation in response to DNA damage, for homologous recombination repair and for cellular resistance to DNA-damaging agents. DeSUMOylation by SENP7 is required to promote a permissive chromatin environment for DNA repair. Enzyme SENP7 is required for localized euchromatin relaxation | Homo sapiens |