Cloned (Comment) | Organism |
---|---|
recombinant exxpression of GFP-tagged SENP7 constructs in NIH-3T3 cell nuclei | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown strategy to deplete SENP7 from NIH-3T3 cells by transfecting a plasmid encoding both a microRNA to downregulate SENP7 and GFP mRNA to enable the identification of microRNA-expressing cells | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | enzyme SENP7 localization at pericentric domains depends on HP1 interaction motifs, the module of two PxVxL interaction motifs on SENP7 maintains HP1 enrichment at pericentric domains, localization study, overview | Mus musculus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | a module of two PxVxL HP1 interaction motifs on enzyme SENP7 mediates association with HP1, molecular basis for the interaction between SENP7 and HP1, the capacity for SENP7 to interact with HP1 in cells and its capacity to de-SUMOylate SUMO1-HP1 are independent | ? | - |
? | |
SUMO1-HP1 + H2O | Mus musculus | deSUMOylation | HP1 + SUMO1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
NIH-3T3 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | a module of two PxVxL HP1 interaction motifs on enzyme SENP7 mediates association with HP1, molecular basis for the interaction between SENP7 and HP1, the capacity for SENP7 to interact with HP1 in cells and its capacity to de-SUMOylate SUMO1-HP1 are independent | Mus musculus | ? | - |
? | |
SUMO1-HP1 + H2O | deSUMOylation | Mus musculus | HP1 + SUMO1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SENP7 SUMO-protease | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | loss of SENP7 leads to an increased time spent in mitosis. Single PxVxL SENP7 mutants behave as dominant negatives | Mus musculus |
metabolism | HP1 enrichment at pericentric heterochromatin is essential for proper chromosome segregation, the process requires H3K9me3 and the SUMO protease SENP7 | Mus musculus |
physiological function | a short module comprising two consecutive HP1 interaction motifs on SENP7 is the determinant for HP1 enrichment and acts by restricting HP1 mobility at pericentric domains. Mechanism for maintenance of HP1 enrichment determination in which this module functions on top of H3K9me3 to lock contiguous HP1 molecules already docked on H3K9me3-modified nucleosomes, overview | Mus musculus |