Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Chloroquine | dose-dependently increases SENP6 protein, but not mRNA, in mouse macrophages, RAW264.7 cells. Chloroquine dose-dependently decreases the levels of microRNA-669n, which bound to 3'-UTR of SENP6 mRNA to inhibit its translation | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q6P7W0 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | - |
Mus musculus | - |
RAW-264.7 cell | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | overexpression of SENP6 in RAW264.7 cells significantly decreases the LPS-induced release of proinflammatory proteins, TNF-alpha, IL-6 and IFN-gamma, while depletion of SENP6 in RAW264.7 cells significantly increases these proteins. In LPS-treated RAW264.7 cells, chloroquine dose-dependently decreases the levels of microRNA-669n, which bound to 3'-UTR of SENP6 mRNA to inhibit its translation. Overexpression of microR-669n decreases SENP6, resulting in increased production of TNF-alpha, IL-6 and IFN-gamma in RAW264.7 cells, while depletion of microR-669n increases SENP6 | Mus musculus |