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Literature summary for 3.4.22.B72 extracted from

  • Liu, Y.; Yu, F.; Han, Y.; Li, Q.; Cao, Z.; Xiang, X.; Jiang, S.; Wang, X.; Lu, J.; Lai, R.; Wang, H.; Cai, W.; Bao, S.; Xie, Q.
    SUMO-specific protease 3 is a key regulator for hepatic lipid metabolism in non-alcoholic fatty liver disease (2016), Sci. Rep., 6, 37351 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H4L4
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Rattus norvegicus G3V7S5
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Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
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 Homo sapiens
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blood plasma
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 Rattus norvegicus
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liver
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 Homo sapiens
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liver
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 Rattus norvegicus
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General Information

General Information Comment Organism
physiological function hepatic SENP3 is upregulated in a nonalcoholic fatty liver disease model in vivo and after loading hepatocytes with free fatty acids in vitro. SENP3 gene silencing is associated in vitro with amelioration of lipid accumulation and overexpression with enhancement of lipid accumulation Rattus norvegicus
physiological function hepatic SENP3 is upregulated in nonalcoholic fatty liver disease patients and after loading hepatocytes with free fatty acids in vitro. SENP3 gene silencing is associated in vitro with amelioration of lipid accumulation and overexpression with enhancement of lipid accumulation. Among SENP3 related genes in nonalcoholic fatty liver disease, apoe, a2m and tnfrsf11b are regulated by SENP3 with free fatty acid stimulation Homo sapiens