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Literature summary for 3.4.22.B72 extracted from
- SENP3 grants tight junction integrity and cytoskeleton architecture in mouse Sertoli cells (2017), Oncotarget, 8, 58430-58442 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | SENP3 is predominantly expressed in the nucleus of Sertoli and spermatocyte cells in adult mouse testis | Mus musculus | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9EP97 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | - |
Mus musculus | - |
| Sertoli cell | - |
Mus musculus | - |
| spermatocyte | - |
Mus musculus | - |
| testis | - |
Mus musculus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | knockdown of SENP3 compromises tight junctions in Sertoli cells by destructing the permeability function with a concomitant decline in trans-epithelial electrical resistance in primary Sertoli cells. SENP3 knockdown disrupts F-actin architecture in Sertoli cells through intervening Rac1/CDC42-N-WASP-Arp2/3 signaling pathway and Profilin-1 abundance | Mus musculus |
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