Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | weak expression in cytoplasm | Homo sapiens | 5737 | - |
nucleus | predominantly localized in the nucleus | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(SUMO-2/3)-promyelocytic leukemia protein + H2O | Homo sapiens | SENP3 appears to be a key mediator in mild oxidative stress-induced cell proliferation via regulation of the SUMOylation status of promyelocytic leukemia protein. SENP3-mediated de-conjugation of SUMO2/3 from PML is responsible for accelerated cell proliferation and decreased promyelocytic leukemia bodies under mild oxidative stress | SUMO-2/3 + promyelocytic leukemia protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9H4L4 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colonic adenocarcinoma cell | SENP3 is over-accumulated in a variety of primary human cancers including colon adenocarcinoma. SENP3-mediated de-SUMO2/3 of promyelocytic leukemia might contribute to the development or progression of human cancers | Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
HUVEC cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(SUMO-2/3)-promyelocytic leukemia protein + H2O | - |
Homo sapiens | SUMO-2/3 + promyelocytic leukemia protein | - |
? | |
(SUMO-2/3)-promyelocytic leukemia protein + H2O | SENP3 appears to be a key mediator in mild oxidative stress-induced cell proliferation via regulation of the SUMOylation status of promyelocytic leukemia protein. SENP3-mediated de-conjugation of SUMO2/3 from PML is responsible for accelerated cell proliferation and decreased promyelocytic leukemia bodies under mild oxidative stress | Homo sapiens | SUMO-2/3 + promyelocytic leukemia protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SENP3 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | low doses of hydrogen peroxide induce an increase of the SENP3 protein | up |
Homo sapiens | SENP3 is over-accumulated in a variety of primary human cancers including colon adenocarcinoma | up |
General Information | Comment | Organism |
---|---|---|
physiological function | SENP3 appears to be a key mediator in mild oxidative stress-induced cell proliferation via regulation of the SUMOylation status of promyelocytic leukemia protein | Homo sapiens |