Literature summary for 3.4.22.B70 extracted from

Zhang, X.; Wang, H.; Wang, H.; Xiao, F.; Seth, P.; Xu, W.; Jia, Q.; Wu, C.; Yang, Y.; Wang, L.
SUMO-specific cysteine protease 1 promotes epithelial mesenchymal transition of prostate cancer cells via regulating SMAD4 deSUMOylation (2017), Int. J. Mol. Sci., 18, 808 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
LNCaP cell	-	Homo sapiens	-
PC-3M cell	prostate cancer cell	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	silencing of SENP1 promotes cellular apoptosis, and inhibits proliferation and migration of PC-3M cells. SENP1 silencing increases the SMAD4 expression at protein level, upregulates E-cadherin and downregulates vimentin expression. SMAD4 interference abolishes SENP1-mediated upregulation of E-cadherin. SENP1 overexpression in LNCaP cells reduces SMAD4 protein, and promotes epithelial mesenchymal transition via decreasing E-cadherin and increasing vimentin	Homo sapiens

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Release 2023.1 (January 2023)