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Literature summary for 3.4.22.B70 extracted from

  • Zhang, H.; Wang, Y.; Zhu, A.; Huang, D.; Deng, S.; Cheng, J.; Zhu, M.X.; Li, Y.
    SUMO-specific protease 1 protects neurons from apoptotic death during transient brain ischemia/reperfusion (2016), Cell Death Dis., 7, e2484 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B70

Organism

Organism UniProt Comment Textmining
Mus musculus P59110
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Mus musculus
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neuron
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 Mus musculus
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General Information

General Information Comment Organism
physiological function transient middle cerebral artery occlusion in mice followed by 6, 12 and 24 h reperfusion significantly enhances SENP1 levels in the affected brain area, independent of transcription. The levels of SUMO1-conjugated proteins are decreased by schemia/reperfusion in cortical neurons of control littermate mice, but unchanged in that of animals with conditional ablation of SENP1 gene from adult principal neurons. The SENP1 cKO mice exhibit a significant increase in infarct volume in the cerebral cortex and more severe motor impairment in response to schemia/reperfusion as compared with the control littermates. Cortical neurons from schemia/reperfusion-injured SENP1 cKO mice become more apoptotic than that from control littermates. Overexpression of SENP1 in somatosensory cortices of adult wild-type (WT) mice suppresses schemia/reperfusion-induced neuronal apoptosis Mus musculus