Literature summary for 3.4.22.B70 extracted from

Huang, X.; Zuo, Y.; Wang, X.; Wu, X.; Tan, H.; Fan, Q.; Dong, B.; Xue, W.; Chen, G.Q.; Cheng, J.
SUMO-specific protease 1 is critical for myeloid-derived suppressor cell development and function (2019), Cancer Res., 79, 3891-3902 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P59110	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
SUMOylated CD45 + H2O	SENP1 can deconjugate SUMOylated CD45	Mus musculus	?	-	?

General Information

General Information	Comment	Organism
physiological function	SENP1 regulates the development and function of myeloid-derived suppressor cells. SENP1 deficiency in myeloid cells promotes myeloid-derived suppressor cell expansion in bone marrow, spleen, and other organs. Senp1-/- myeloid-derived suppressor cell show stronger immunosuppressive activity than Senp1+/+ myeloid-derived suppressor cells. No defects in the differentiation of myeloid precursor cells are observed in Senp1-/- mice. SENP1-mediated regulation of myeloid-derived suppressor cell is dependent on STAT3 signaling. CD45 is SUMOylated in myeloid-derived suppressor cells and SENP1 can deconjugate SUMOylated CD45	Mus musculus

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Release 2023.1 (January 2023)