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Literature summary for 3.4.22.B70 extracted from

  • Liu, B.; Wang, T.; Mei, W.; Li, D.; Cai, R.; Zuo, Y.; Cheng, J.
    Small ubiquitin-like modifier (SUMO) protein-specific protease 1 de-SUMOylates Sharp-1 protein and controls adipocyte differentiation (2014), J. Biol. Chem., 289, 22358-22364.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant enzymes in MEF, 293T, and 3T3-L1 cells, real-time quantitative PCR expression analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Sharp-1 protein + H2O Homo sapiens deSUMOylation by the enzyme ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9P0U3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Sharp-1 protein + H2O deSUMOylation by the enzyme Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
SENP1
-
 Homo sapiens
sentrin-specific protease 1 UniProt Homo sapiens
small ubiquitin-like modifier protein-specific protease 1
-
 Homo sapiens
SUMO protein-specific protease 1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction defects in adipocyte differentiation as well as PPARgamma expression in Senp1-/- mouse embryonic fibroblast cells induced by adipogenic stimuli. Deficiency in SUMOylation reduces Sharp-1 suppression of adipogenesis Homo sapiens
physiological function the enzyme controls adipocyte differentiation. Adipocyte differentiation is regulated by a transcriptional cascade that mainly includes CCAAT/enhancer-binding protein family members and the nuclear receptor peroxisome proliferator-activated receptor gamma, PPARgamma. SENP1 is a specific de-SUMOylation protease for Sharp-1, a repressor for PPARgamma transcription and adipogenesis. SENP1 enhances adipogenesis through de-SUMOylation of Sharp-1, which then releases Sharp-1 repression of PPARgamma expression and adipocyte differentiation Homo sapiens