Literature summary for 3.4.22.B70 extracted from

Cai, R.; Yu, T.; Huang, C.; Xia, X.; Liu, X.; Gu, J.; Xue, S.; Yeh, E.T.; Cheng, J.
SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1alpha (2012), J. Biol. Chem., 287, 44464-44470.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
SUMOylated peroxisome proliferator-activated receptor coactivator 1alpha + H2O	deSUMOylation	Homo sapiens	deSUMOylated peroxisome proliferator-activated receptor coactivator 1alpha + SUMO1	-	?

Synonyms

Synonyms	Comment	Organism
SENP1	-	Homo sapiens
sentrin/SUMO-specific protease 1	-	Homo sapiens
SUMO-specific protease 1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	SENP1 is a specific protease to regulate the SUMOylation status of peroxisome proliferator-activated receptor coactivator 1alpha, i.e. PGC-1alpha. The enzyme SENP1 also promotes PGC-1alpha transcription activity, which is essential for the expression of mitochondrial genes and subsequently mitochondrial biogenesis. SENP1 is essential for expression of nuclear mitochondrial genes	Homo sapiens

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Release 2023.1 (January 2023)