Application | Comment | Organism |
---|---|---|
medicine | SENP1 overexpression induces transformation of the normal prostate gland and gradually facilitates the onset of high-grade prostatic intraepithelial neoplasiade. SUMOylation plays a critical role in prostate pathogenesis through induction of HIF1alpha-dependent angiogenesis and enhanced cell proliferation | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
SUMO-hypoxia-inducible factor 1 conjugate + H2O | Mus musculus | deSUMOylation plays a critical role in prostate pathogenesis through induction of HIF1alpha-dependent angiogenesis and enhanced cell proliferation | SUMO + hypoxia-inducible factor 1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P59110 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
prostate | SENP1 modulates prostate epithelial cell proliferation | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
SUMO-hypoxia-inducible factor 1 conjugate + H2O | - |
Mus musculus | SUMO + hypoxia-inducible factor 1 | - |
? | |
SUMO-hypoxia-inducible factor 1 conjugate + H2O | deSUMOylation plays a critical role in prostate pathogenesis through induction of HIF1alpha-dependent angiogenesis and enhanced cell proliferation | Mus musculus | SUMO + hypoxia-inducible factor 1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SENP1 | - |
Mus musculus |