Literature summary for 3.4.22.B70 extracted from

Dai, X.Q.; Plummer, G.; Casimir, M.; Kang, Y.; Hajmrle, C.; Gaisano, H.Y.; Manning Fox, J.E.; MacDonald, P.E.
SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans (2011), Diabetes, 60, 838-847.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P59110	-	-

General Information

General Information	Comment	Organism
malfunction	SENP1 knockdown impairs exocytosis at stimulatory glucose levels and blunts glucose-dependent insulin secretion from mouse and human islets. SENP1 overexpression also disrupts the association of SUMO1 with synaptotagmin VII and mimics the effect of glucose to enhance exocytosis	Mus musculus
physiological function	SENP1, is required for glucose-dependent insulin secretion. SUMOylation acutely regulates insulin secretion by the direct and reversible inhibition of beta-cell exocytosis in response to intracellular Ca(2+) elevation	Mus musculus

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Release 2023.1 (January 2023)