Literature summary for 3.4.22.B70 extracted from

Li, X.; Luo, Y.; Yu, L.; Lin, Y.; Luo, D.; Zhang, H.; He, Y.; Kim, Y.O.; Kim, Y.; Tang, S.; Min, W.
SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis (2008), Cell Death Differ., 15, 739-750.

Search for more literature for 3.4.22.B70

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	SENP1 is localized in the cytoplasm where it is complexed with an antioxidant protein thioredoxin. Tumor necrosis factor (TNF) induces the release of SENP1 from thioredoxin as well as nuclear translocation of SENP1	Homo sapiens	5737	-
nucleus	SENP1 is localized in the cytoplasm where it is complexed with an antioxidant protein thioredoxin. Tumor necrosis factor (TNF) induces the release of SENP1 from thioredoxin as well as nuclear translocation of SENP1	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9P0U3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelial cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
SUMO-homeodomain-interacting protein kinase 1 conjugate + H2O	-	Homo sapiens	SUMO + homeodomain-interacting protein kinase 1 conjugate	-	?

Synonyms

Synonyms	Comment	Organism
SENP1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance apoptosis signal-regulating kinase-1-dependent apoptosis	Homo sapiens

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Release 2023.1 (January 2023)