Literature summary for 3.4.22.B35 extracted from

Hastings, M.H.; Qiu, A.; Zha, C.; Farah, C.A.; Mahdid, Y.; Ferguson, L.; Sossin, W.S.
The zinc fingers of the small optic lobes calpain bind polyubiquitin (2018), J. Neurochem., 146, 429-445 .

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Organism

Organism	UniProt	Comment	Textmining
Aplysia californica	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	sensory neuron	Mus musculus	-
neuron	sensory neuron	Aplysia californica	-

Synonyms

Synonyms	Comment	Organism
small optic lobes calpain	-	Mus musculus
small optic lobes calpain	-	Aplysia californica
SOL calpain	-	Mus musculus
SOL calpain	-	Aplysia californica

General Information

General Information	Comment	Organism
physiological function	SOL calpain zinc fingers bind poly- but not mono- or diubiquitin. No specific zinc finger is required for polyubiquitin binding. Neither polyubiquitin nor calcium is sufficient to induce purified SOL calpain to autolyse or to cleave the atypical protein kinase C to protein kinase M in vitro. In Aplysia californica, overexpression of the atypical protein kinase C in sensory neurons leads to an activity-dependent cleavage event and an increase in nuclear ubiquitin staining. Activity-dependent cleavage is partially blocked by a dominant negative SOL calpain	Aplysia californica
physiological function	SOL calpain zinc fingers bind to ubiquitin. No specific zinc finger is required for polyubiquitin binding	Mus musculus

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Release 2023.1 (January 2023)