Activating Compound | Comment | Organism | Structure |
---|---|---|---|
angiotensin II | activates the enzyme in vivo, reduced by pan-calpain inhibitors | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a potential target for the development of drug therapies for the treatment of hypertension | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | siRNA-mediated knockdown of calpain-10 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | pan-calpain inhibitors reduce AngII-induced aldosterone production in 2 adrenal glomerulosa cell models, primary bovine zona glomerulosa and human adrenocortical carcinoma cells | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9HC96 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal glomerulosa cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
calpain-10 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | siRNA-mediated knockdown of calpain-10 inhibits aldosterone production and CYP11B2 expression, whereas adenovirus-mediated overexpression of calpain-10 results in increased AngII-induced aldosterone production | Homo sapiens |
physiological function | calpain-10 activity underlies angiotensin II-induced aldosterone production in an adrenal glomerulosa cell model | Homo sapiens |