Literature summary for 3.4.22.B30 extracted from

Lopez-Orduna, E.; Garcia-Mena, J.; Garcia-Macedo, R.; Stumvoll, M.; Cruz, M.
CAPN10 mRNA splicing and decay is not affected by a SNP associated with susceptibility to type 2 diabetes (2007), Biochem. Biophys. Res. Commun., 358, 831-836.

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Application

Application	Comment	Organism
medicine	type 2 diabetes mellitus patients with the SNP-43 G-allele have 4.6fold more CAPN10 transcripts compared to subjects with the A-allele. The mRNA half-life of this transcript in 293T cells (SNP-43 G/G) and Jurkat cells (SNP-43 A/A) is of 8 h. In type 2 diabetes mellitus subjects the G-allele increases the CAPN10 mRNA levels. It is proposed that a defective CAPN10 pre-mRNA processing is responsible for the decreased levels of SNP-43 A-allele transcripts in peripheral white cells of healthy and T2D individuals	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9HC96	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leukocyte	it is proposed that a defective CAPN10 pre-mRNA processing is responsible for the decreased levels of SNP-43 A-allele transcripts in peripheral white cells of healthy and T2D individuals	Homo sapiens	-

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Release 2023.1 (January 2023)