Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
IkappaBalpha-ubiquitin + H2O | Yersinia sp. | - |
IkappaBalpha + ubiquitin | - |
? | |
TRAF2-ubiquitin + H2O | Yersinia sp. | - |
TRAF2 + ubiquitin | - |
? | |
TRAF6-ubiquitin + H2O | Yersinia sp. | - |
TRAF6 + ubiquitin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Yersinia sp. | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
IkappaBalpha-ubiquitin + H2O | - |
Yersinia sp. | IkappaBalpha + ubiquitin | - |
? | |
additional information | YopH is a tyrosine phosphatase | Yersinia sp. | ? | - |
? | |
additional information | YopJ uses acetyl-coenzyme A to modify the critical serine and threonine residues in the activation loop of MAPKK6 and thereby blocking phosphorylation | Yersinia sp. | ? | - |
? | |
TRAF2-ubiquitin + H2O | - |
Yersinia sp. | TRAF2 + ubiquitin | - |
? | |
TRAF6-ubiquitin + H2O | - |
Yersinia sp. | TRAF6 + ubiquitin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Yersinia outer protein | - |
Yersinia sp. |
YopJ | - |
Yersinia sp. |
General Information | Comment | Organism |
---|---|---|
physiological function | YopJ deactivates MAPK- and NF-kappaB signaling pathways, and induces apoptosis of immune cells, YopJ inhibits the c-JNK pathway, attenuates the inflammatory responses, and interferes with the cell apoptotic process. When YopJ is replaced with YopP, the YopP-expressing Yersinia pestis strain exhibits high cytotoxic activity against macrophages | Yersinia sp. |