Literature summary for 3.4.22.B19 extracted from

Bliska, J.B.
Yersinia inhibits host signaling by acetylating MAPK kinases (2006), ACS Chem. Biol., 1, 349-351.

Search for more literature for 3.4.22.B19

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Yersinia pseudotuberculosis	pathogenic Yersinia spp. secrete the effector YopJ into host cells to counteract cytokine production and to induce programmed cell death. YopJ achieves these aims by inactivating mitogen-activated protein kinase and nuclear factor kappaB signaling pathways. YopJ binds to members of the MAPK kinase family and is predicted to have protease activity toward ubiquitin-like proteins	?	-	?
additional information	Yersinia pestis	pathogenic Yersinia spp. secrete the effector YopJ into host cells to counteract cytokine production and to induce programmed cell death. YopJ achieves these aims by inactivating mitogen-activated protein kinase and nuclear factor kappaB signaling pathways. YopJ binds to members of the MAPK kinase family and is predicted to have protease activity toward ubiquitin-like proteins	?	-	?
additional information	Yersinia enterocolitica	pathogenic Yersinia spp. secrete the effector YopJ into host cells to counteract cytokine production and to induce programmed cell death. YopJ achieves these aims by inactivating mitogen-activated protein kinase and nuclear factor kappaB signaling pathways. YopJ binds to members of the MAPK kinase family and is predicted to have protease activity toward ubiquitin-like proteins	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Yersinia enterocolitica	-	-	-
Yersinia pestis	-	-	-
Yersinia pseudotuberculosis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	pathogenic Yersinia spp. secrete the effector YopJ into host cells to counteract cytokine production and to induce programmed cell death. YopJ achieves these aims by inactivating mitogen-activated protein kinase and nuclear factor kappaB signaling pathways. YopJ binds to members of the MAPK kinase family and is predicted to have protease activity toward ubiquitin-like proteins	Yersinia pseudotuberculosis	?	-	?
additional information	pathogenic Yersinia spp. secrete the effector YopJ into host cells to counteract cytokine production and to induce programmed cell death. YopJ achieves these aims by inactivating mitogen-activated protein kinase and nuclear factor kappaB signaling pathways. YopJ binds to members of the MAPK kinase family and is predicted to have protease activity toward ubiquitin-like proteins	Yersinia pestis	?	-	?
additional information	pathogenic Yersinia spp. secrete the effector YopJ into host cells to counteract cytokine production and to induce programmed cell death. YopJ achieves these aims by inactivating mitogen-activated protein kinase and nuclear factor kappaB signaling pathways. YopJ binds to members of the MAPK kinase family and is predicted to have protease activity toward ubiquitin-like proteins	Yersinia enterocolitica	?	-	?

Synonyms

Synonyms	Comment	Organism
YopJ	-	Yersinia pseudotuberculosis
YopJ	-	Yersinia pestis
YopP	-	Yersinia enterocolitica

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Release 2023.1 (January 2023)