Literature summary for 3.4.22.66 extracted from

Kim, Y.; Shivanna, V.; Narayanan, S.; Prior, A.M.; Weerasekara, S.; Hua, D.H.; Kankanamalage, A.C.; Groutas, W.C.; Chang, K.O.
Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline caliciviruses (2015), J. Virol., 89, 4942-4950 .

Inhibitors

Inhibitors	Comment	Organism
benzyl [(2S)-1-[[(2S)-3-methyl-1-oxo-1-([(2S)-1-oxo-3-[(1S)-2-oxocyclopentyl]propan-2-yl]amino)butan-2-yl]amino]-3-(naphthalen-1-yl)-1-oxopropan-2-yl]carbamate	tripeptidyl compound, potent antiviral activities against both feline coronavirus strain WSU-79-1146 and feline calicivirus strain Urbana. Treatment of coronavirus-infected mice with the compound at 100 mg/kg results in a significant reduction in liver virus titers	feline calicivirus
benzyl [(2S)-1-[[(2S)-3-methyl-1-oxo-1-([(2S)-1-oxo-3-[(1S)-2-oxocyclopentyl]propan-2-yl]amino)butan-2-yl]amino]-3-(naphthalen-1-yl)-1-oxopropan-2-yl]carbamate	tripeptidyl compound, potent antiviral activities against both feline coronavirus strain WSU-79-1146 and feline calicivirus strain Urbana. Treatment of coronavirus-infected mice with the compound at 100 mg/kg results in a significant reduction in liver virus titers	feline coronavirus
N2-[(benzyloxy)carbonyl]-N-[(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]-1-(sulfinooxy)propan-2-yl]-L-valinamide	dipeptidyl compound, statistically significant reduction in the viral load in the liver of virus-infected mice is consistently observed	feline calicivirus
N2-[(benzyloxy)carbonyl]-N-[(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]-1-(sulfinooxy)propan-2-yl]-L-valinamide	dipeptidyl compound, statistically significant reduction in the viral load in the liver of virus-infected mice is consistently observed	feline coronavirus

Organism	UniProt	Comment	Textmining
feline calicivirus	-	-	-
feline calicivirus Urbana	-	-	-
feline coronavirus	-	-	-
feline coronavirus FIPV WSU-79/1146	-	-	-