Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.64 extracted from

  • Flood, B.; Manils, J.; Nulty, C.; Flis, E.; Kenealy, S.; Barber, G.; Fay, J.; Mills, K.H.G.; Kay, E.W.; Creagh, E.M.
    Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis (2019), Oncogene, 38, 2658-2674 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.64

Organism

Organism UniProt Comment Textmining
Mus musculus P70343
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
 Mus musculus
-
intestine
-
 Mus musculus
-

General Information

General Information Comment Organism
physiological function Casp11-/- mice are highly susceptible to the azoxymethane dextran sulfate sodium model of colitis-associated cancer, compared to their wild-type littermates. Deficient IL-18 production occurs at initial inflammation stages of disease, and IL-1beta production is more significantly impaired in Casp11-/- colons during established colitis-associated cancer. Casp11-/- colons display defective STAT1 activation during disease progression, and IL-1beta signalling induces caspase-11 expression and STAT1 activation in primary murine macrophages and intestinal epithelial cells Mus musculus