Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.64 extracted from

  • Sun, Y.; Abbondante, S.; Karmakar, M.; De Jesus Carrion, S.; Che, C.; Hise, A.; Pearlman, E.
    Neutrophil caspase-11 is required for cleavage of caspase-1 and secretion of IL-1beta in Aspergillus fumigatus infection (2018), J. Immunol., 201, 2767-2775 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.64

Organism

Organism UniProt Comment Textmining
Mus musculus P70343
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cornea
-
 Mus musculus
-
neutrophil bone marrow neutrophil Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
caspase-1 + H2O
-
 Mus musculus ?
-
 ?

General Information

General Information Comment Organism
physiological function in response to corneal infection with Aspergillus fumigatus, caspase-11-/- mice exhibit the same susceptibility phenotype as IL-1beta-/-, ASC-/-, NLRP3-7-, and caspase-1-/- mice, with impaired neutrophil recruitment to infected corneas and increased hyphal growth. Caspase-11 is required for caspase-1 activation and IL-1eta processing during infection. In vitro, caspase-11 is regulated by the common type I IFN receptor (IFNAR) through JAK-STAT signaling and caspase-11 is required for speck formation and caspase-1 activity Mus musculus