Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the cholera toxin B subunit and many different Gram-negative bacteria can trigger Caspase-11 activation in vitro. Cytosolic infection of cells with Burkholderia species and cytyosolic mutants of Salmonella typhimurium and Legionella pneumophila trigger the enzyme | Mus musculus |
Cloned (Comment) | Organism |
---|---|
gene Casp11 | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of Casp11-/- mice, all existing caspase-1 deficient mice also lack Caspase-11 due to the backcrossing of a mutant Casp11 allele from 129 into C57BL/6 mice | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
gene Casp11 | - |
Mus musculus C57BL/6 | - |
gene Casp11 | - |
Organism | Comment | Expression |
---|---|---|
Mus musculus | cytosolic infection of cells with Burkholderia species and cytyosolic mutants of Salmonella typhimurium and Legionella pneumophila trigger the enzyme | up |
General Information | Comment | Organism |
---|---|---|
malfunction | all existing caspase-1 deficient mice also lack Caspase-11 due to the backcrossing of a mutant Casp11 allele from 129 into C57BL/6 mice | Mus musculus |
metabolism | while Salmonella typhimurium and Legionella pneumophila normally reside in the vacuole, specific mutants (sifA and sdhA, respectively) that aberrantly enter the cytosol trigger Caspase-11, enhancing clearance of S. typhimurium sifA in vivo. This response does not require NLRP3, NLRC4, or ASC inflammasome pathways. Burkholderia species that naturally invade the cytosol also trigger Caspase-11, protecting mice from lethal challenge with Burkholderia thailandensis and Burkholderia pseudomallei. Caspase-11 is critical for surviving exposure to ubiquitous environmental pathogens | Mus musculus |
physiological function | caspase-11 is an inflammatory caspase that can also promote interleukin-1beta secretion dependent upon NLRP3, ASC, and Caspase-1. Inflammatory caspase-11 triggers pyroptosis, a form of programmed cell death. The enzyme can be detrimental in inflammatory disease,but has no protective role during infection. Caspase-11 is required for innate immunity to cytosolic, but not vacuolar, bacteria | Mus musculus |