Literature summary for 3.4.22.64 extracted from

Py, B.F.; Jin, M.; Desai, B.N.; Penumaka, A.; Zhu, H.; Kober, M.; Dietrich, A.; Lipinski, M.M.; Henry, T.; Clapham, D.E.; Yuan, J.
Caspase-11 controls interleukin-1beta release through degradation of TRPC1 (2014), Cell Rep., 6, 1122-1128.

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Cloned(Commentary)

Cloned (Comment)	Organism
gene CASP11, overexpression of FLAG-tagged enzyme in HEK-293T cells, co-expression with HA-tagged cationic channel subunit transient receptor potential channel 1, i.e. TRPC1, subunits p10 and p20 of caspase-11, but not caspase recruitment domain (CARD) alone, is co-immunoprecipitated with TRPC1. FLAG-tagged caspase-11 is able to co-immunoprecipitate independently with HA-tagged TRPC1 N-terminal alone, the N-terminal domain with the transmembrane domain, and the transmembrane domain with the C-terminal domain, but not with the central transmembrane domain alone	Mus musculus

Cloned (Comment)

Organism

gene CASP11, overexpression of FLAG-tagged enzyme in HEK-293T cells, co-expression with HA-tagged cationic channel subunit transient receptor potential channel 1, i.e. TRPC1, subunits p10 and p20 of caspase-11, but not caspase recruitment domain (CARD) alone, is co-immunoprecipitated with TRPC1. FLAG-tagged caspase-11 is able to co-immunoprecipitate independently with HA-tagged TRPC1 N-terminal alone, the N-terminal domain with the transmembrane domain, and the transmembrane domain with the C-terminal domain, but not with the central transmembrane domain alone

Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
cationic channel subunit transient receptor potential channel 1 + H2O	Mus musculus	i.e. TRPC1, plays a role in regulating innate immunity by modulating channel complexes during inflammatory responses	?	-	?
cationic channel subunit transient receptor potential channel 1 + H2O	Mus musculus C57B6	i.e. TRPC1, plays a role in regulating innate immunity by modulating channel complexes during inflammatory responses	?	-	?
additional information	Mus musculus	other caspases are substrates of caspase-11	?	-	?
additional information	Mus musculus C57B6	other caspases are substrates of caspase-11	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Mus musculus C57B6	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
cationic channel subunit transient receptor potential channel 1 + H2O	i.e. TRPC1, plays a role in regulating innate immunity by modulating channel complexes during inflammatory responses	Mus musculus	?	-	?
cationic channel subunit transient receptor potential channel 1 + H2O	-	Mus musculus	?	-	?
cationic channel subunit transient receptor potential channel 1 + H2O	i.e. TRPC1, plays a role in regulating innate immunity by modulating channel complexes during inflammatory responses	Mus musculus C57B6	?	-	?
cationic channel subunit transient receptor potential channel 1 + H2O	-	Mus musculus C57B6	?	-	?
additional information	other caspases are substrates of caspase-11	Mus musculus	?	-	?
additional information	other caspases are substrates of caspase-11	Mus musculus C57B6	?	-	?

General Information

General Information	Comment	Organism
evolution	caspase-11 is a member of the caspase family of cysteine proteases	Mus musculus
physiological function	caspase-11 is a highly inducible caspase that controls both inflammatory responses and cell death. Caspase-11 controls interleukin 1beta secretion by potentiating caspase-1 activation and induces caspase-1-independent pyroptosis downstream of noncanonical NLRP3 inflammasome activators such as lipopolysaccharide and Gram-negative bacteria. Caspase-11 modulates the cationic channel composition of the cell and thus regulates the unconventional secretion pathway in a manner independent of caspase-1. Caspase-11 controls the TRPC1-dependent decrease in cytosolic Ca2+ following lipopolysaccharide treatment	Mus musculus