Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | caspase-9/-3 activation in differentiated cells, inhibited by protein kinase C (PKC) and the mitogen activated protein kinase (MEK) signaling pathways | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-caspase-3 + H2O | Homo sapiens | caspase-9/-3 activation in differentiated cells can be prevented by protein kinase C (PKC) and the mitogen activated protein kinase (MEK) signaling pathways | caspase-3 + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P55211 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | undifferentiated and differentiated cells, differentiation induced by phorbol-12-myristate-13-acetate (TPA) | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
RC-RNase-induced caspase-9/-3-mediated cytotoxicity in undifferentiated and differentiated cells, cell differentiation and adhesion assays, cell proliferation assays, caspase-9/-3-mediated cytotoxicity can be induced in differentiated cells that are pretreated with inhibitors of protein kinase C (PKC) or mitogen activated protein kinase (MEK), caspases-9/-3-mediated cytotoxicity in differentiated cells inhibited by protein kinase C (PKC) and the mitogen activated protein kinase (MEK) signaling pathways | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-Asp-Glu-Val-Asp-p-nitroanilide + H2O | i.e. Ac-DEVD-pNA, caspase-9/-3 activation in differentiated cells can be prevented by protein kinase C (PKC) and the mitogen activated protein kinase (MEK) signaling pathways | Homo sapiens | acetyl-Asp-Glu-Val-Asp + p-nitroaniline | - |
? | |
acetyl-Leu-Glu-His-Asp-p-nitroanilide + H2O | i.e. Ac-LEHD-pNA, caspase-9/-3 activation in differentiated cells can be prevented by protein kinase C (PKC) and the mitogen activated protein kinase (MEK) signaling pathways | Homo sapiens | acetyl-Leu-Glu-His-Asp + p-nitroaniline | - |
? | |
pro-caspase-3 + H2O | caspase-9/-3 activation in differentiated cells can be prevented by protein kinase C (PKC) and the mitogen activated protein kinase (MEK) signaling pathways | Homo sapiens | caspase-3 + ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
caspase activity assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
caspase activity assay at | Homo sapiens |