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Literature summary for 3.4.22.62 extracted from

  • Yan, X.; Feng, C.; Chen, Q.; Li, W.; Wang, H.; Lv, L.; Smith, G.W.; Wang, J.
    Effects of sodium fluoride treatment in vitro on cell proliferation, apoptosis and caspase-3 and caspase-9 mRNA expression by neonatal rat osteoblasts (2008), Arch. Toxicol., 83, 451-458.
    View publication on PubMed
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Application

Application Comment Organism
pharmacology NaF-induced apoptosis of osteoblasts, in vitro studies, pronounced negative effect of NaF treatment on indices of survival of osteoblasts, decreased proliferation, increased apoptosis and increased caspase-3 and caspase-9 mRNA Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
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 Rattus norvegicus 5737
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Metals/Ions

Metals/Ions Comment Organism Structure
NaF NaF-induced apoptosis of osteoblasts Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus effect of fluoride treatment (NaF) on osteoblast proliferation, apoptosis and expression of caspase-9 mRNA in vitro ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 neonatal Wistar rats
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Source Tissue

Source Tissue Comment Organism Textmining
osteoblast incubated with 0.5-30 mg/l of sodium fluoride (NaF) Rattus norvegicus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 increase in osteoblast apoptosis observed after 24 and 72 h treatment in response to the lowest dose of sodium fluoride (0.5 mg/l), osteoblast apoptosis also increased in response to higher doses, mRNA of caspase-9 increased in response to sodium fluoride treatment (5 mg/l) for 72 h, morphological and histochemical characterization of osteoblasts, cell proliferation and apoptosis assays, quantification of mRNA expression of caspase-3 and caspase-9 by real time PCR Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information effect of fluoride treatment (NaF) on osteoblast proliferation, apoptosis and expression of caspase-9 mRNA in vitro Rattus norvegicus ?
-
 ?