Literature summary for 3.4.22.61 extracted from

Liedtke, C.; Groeger, N.; Manns, M.P.; Trautwein, C.
Interferon-alpha enhances TRAIL-mediated apoptosis by up-regulating caspase-8 transcription in human hepatoma cells (2006), J. Hepatol., 44, 342-349.

Search for more literature for 3.4.22.61

Activating Compound

Activating Compound	Comment	Organism	Structure
interferon-alpha	increases caspase-8 transcription	Homo sapiens
additional information	combination of interferon-alpha/TRAIL increases activity significantly	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
28000	-	activated heterodimer, gel filtration	Homo sapiens
54000	-	monomer, pro-caspase-8, SDS-PAGE	Homo sapiens
55000	-	monomer, pro-caspase-8, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q14790	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Huh-7 cell	Huh7 hepatoma cell	Homo sapiens	-

Subunits

Subunits	Comment	Organism
dimer	alphabeta, gel filtration	Homo sapiens

Synonyms

Synonyms	Comment	Organism
caspase-8	-	Homo sapiens

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Release 2023.1 (January 2023)