Activating Compound | Comment | Organism | Structure |
---|---|---|---|
N6-(2-isopentenyl)adenosine | highly induces enzyme activation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-alpha-tosyl-L-lysyl-chloromethylketone | i.e. TLCK, substantially inhibits caspase-7 enzymatic DEVDase activity, but does not affect caspase-7 processing in cells exposed to pro-apoptotic inducing stimuli, irreversibly alkylates cysteine residues of the active site of cysteine proteases | Homo sapiens | |
N-tosyl-L-phenylalanyl-chloromethylketone | i.e. TPCK, enhances caspase-7 processing although it substantially inhibits caspase-7 enzymatic DEVDase activity in HL-60 cells exposed to various cell death inducing stimuli, irreversibly alkylates cysteine residues of the active site of cysteine proteases | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | inhibition of executioner caspase enzymatic activity by TLCK and TPCK in dying HL-60 cells is important in prevention of cell death | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ac-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin + H2O | a caspase-3 substrate | Homo sapiens | Ac-Asp-Glu-Val-Asp + 7-amino-4-methylcoumarin | - |
? | |
additional information | inhibition of executioner caspase enzymatic activity by TLCK and TPCK in dying HL-60 cells is important in prevention of cell death | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DEVDase | - |
Homo sapiens |