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Literature summary for 3.4.22.57 extracted from

  • An, J.; Kim, S.H.; Hwang, D.; Lee, K.E.; Kim, M.J.; Yang, E.G.; Kim, S.Y.; Chung, H.S.
    Caspase-4 disaggregates lipopolysaccharide micelles via LPS-CARD interaction (2019), Sci. Rep., 9, 826 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P49662
-
-

Purification (Commentary)

Purification (Comment) Organism
since caspase-4 (C258A) purified from an Escherichia coli host forms aggregates, monomeric proteins including full-length caspase-4, caspase-4 (C258A), and the CARD domain of caspase-4 are purified from the insect cell system Homo sapiens

General Information

General Information Comment Organism
physiological function caspase-4 is a receptor for intracellular LPS, and induces non-canonical inflammasome formation and pyroptosis. Caspase-4 disaggregates lipopolysaccharide micelles via LPS-CARD interaction Homo sapiens