Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P49662 | - |
- |
Purification (Comment) | Organism |
---|---|
since caspase-4 (C258A) purified from an Escherichia coli host forms aggregates, monomeric proteins including full-length caspase-4, caspase-4 (C258A), and the CARD domain of caspase-4 are purified from the insect cell system | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | caspase-4 is a receptor for intracellular LPS, and induces non-canonical inflammasome formation and pyroptosis. Caspase-4 disaggregates lipopolysaccharide micelles via LPS-CARD interaction | Homo sapiens |