Inhibitors | Comment | Organism | Structure |
---|---|---|---|
OspC3 | the effector molecule of Shigella flexneri interacts with the caspase-4-p19 subunit and inhibits its activation by preventing caspase-4-p19 and caspase-4-p10 heterodimerization by depositing the conserved OspC3 X1-Y-X2-D-X3 motif at the putative catalytic pocket of caspase-4 | Cavia porcellus | |
OspC3 | the effector molecule of Shigella flexneri interacts with the caspase-4-p19 subunit and inhibits its activation by preventing caspase-4-p19 and caspase-4-p10 heterodimerization by depositing the conserved OspC3 X1-Y-X2-D-X3 motif at the putative catalytic pocket of caspase-4 | Homo sapiens | |
Z-VAD | - |
Cavia porcellus | |
Z-VAD | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
LEVD-7-amido-4-trifluoromethylcoumarin + H2O | Cavia porcellus | - |
LEVD + 7-amino-4-trifluoromethylcoumarin | - |
? | |
LEVD-7-amido-4-trifluoromethylcoumarin + H2O | Homo sapiens | - |
LEVD + 7-amino-4-trifluoromethylcoumarin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HaCaT cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
LEVD-7-amido-4-trifluoromethylcoumarin + H2O | - |
Cavia porcellus | LEVD + 7-amino-4-trifluoromethylcoumarin | - |
? | |
LEVD-7-amido-4-trifluoromethylcoumarin + H2O | - |
Homo sapiens | LEVD + 7-amino-4-trifluoromethylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CASP4 | - |
Cavia porcellus |
CASP4 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | acute inflammatory cell death in the intestinal tract is mediated by caspase-4 | Cavia porcellus |
physiological function | acute inflammatory cell death in the intestinal tract is mediated by caspase-4 | Homo sapiens |