Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cytochrome c | activates caspase-3 after being released from mitochondria | Homo sapiens |
Application | Comment | Organism |
---|---|---|
diagnostics | caspase-3 is a marker for apoptosis, e.g. useful in patients with urothelial carcinoma of the upper urinary tract, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Bcl-2 | an antiapoptotic protein that is localized to the intracellular membrane, nuclear membrane and endoplasmic reticulum, and blocks caspase activation by inhibiting the mitochondrial release of cytochrome c | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | caspase-3 has a downstream effector function in apoptosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
urinary tract | upper part, expression of caspase-3 is associated with the pathologic stage in urothelial carcinomas, immunohistochemic analysis, overview | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | caspase-3 has a downstream effector function in apoptosis | Homo sapiens | ? | - |
? |