Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-5-[1-(2-methoxymethyl)pyrrolidinylsulfonyl]isatin | IC50: 0.018 mM | Homo sapiens | |
(R)-5-[1-[2-(anilinomethyl)pyrrolidinyl]sulfonyl]isatin | IC50: 0.0055 mM | Homo sapiens | |
(S)-(+)-5-[1-[2-(thiophenoxymethyl)pyrrolidinyl]sulfonyl]isatin | IC50: 44 nM | Homo sapiens | |
(S)-1-(4-pyridinylmethyl)-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonal]isatin | IC50: 4.2 nM | Homo sapiens | |
(S)-1-(carboxymethyl)-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin | IC50: 170 nM | Homo sapiens | |
(S)-1-(cyclohexylmethyl)-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonal]isatin | IC50: 5.2 nM | Homo sapiens | |
(S)-1-allyl-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin | IC50: 4.6 nM | Homo sapiens | |
(S)-1-benzyl-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin | IC50: 2.5 nM | Homo sapiens | |
(S)-1-methyl-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin | IC50: 30 nM | Homo sapiens | |
(S)-1-[(tert-butyloxycarbonyl)methyl]-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin | IC50: 3.1 nM | Homo sapiens | |
(S)-5-[1-(2-methoxymethyl)pyrrolidinylsulfonyl]isatin | IC50: 120 nM | Homo sapiens | |
(S)-5-[1-[(2-methoxycarbonyl)pyrrolidinyl]sulfonyl]isatin | IC50: 170 nM | Homo sapiens | |
(S)-5-[1-[(2-tert-butoxycarbonyl)pyrrolidinyl]sulfonyl]isatin | IC50: 70 nM | Homo sapiens | |
(S)-5-[1-[2-(anilinomethyl)pyrrolidinyl]sulfonyl]isatin | IC50: 31 nM | Homo sapiens | |
(S)-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin | IC50: 44 nM | Homo sapiens | |
(S)-5-[1-[2-(phenylaminocarbonyl)pyrrolidinyl]sulfonyl]isatin | IC50: 140 nM | Homo sapiens | |
(S)-5-[1-[[2-(dimethylamino)carbonyl]pyrrolidinyl]sulfonyl]isatin | IC50: 410 nM | Homo sapiens | |
5-[1-(azetidinyl)sulfonyl]isatin | IC50: 170 nM | Homo sapiens | |
5-[1-(hexamethyleneimino)sulfonyl]isatin | IC50: 0.0019 mM | Homo sapiens | |
5-[1-(piperidinyl)sulfonyl]isatin | IC50: 0.0022 mM | Homo sapiens | |
5-[1-(pyrrolidinyl)sulfonyl]isatin | IC50: 0.0028 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P42574 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chondrocyte | - |
Homo sapiens | - |
JURKAT cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-DEVD-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | acetyl-DEVD + 7-amino-4-methylcoumarin | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000012 | - |
(S)-1-benzyl-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin | pH 7.5, 30°C | Homo sapiens | |
0.000015 | - |
(S)-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin | pH 7.5, 30°C | Homo sapiens | |
0.000019 | - |
(S)-1-[(tert-butyloxycarbonyl)methyl]-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin | pH 7.5, 30°C | Homo sapiens | |
0.00006 | - |
(S)-5-[1-(2-methoxymethyl)pyrrolidinylsulfonyl]isatin | pH 7.5, 30°C | Homo sapiens | |
0.0014 | - |
5-[1-(pyrrolidinyl)sulfonyl]isatin | pH 7.5, 30°C | Homo sapiens | |
0.012 | - |
(R)-5-[1-[2-(anilinomethyl)pyrrolidinyl]sulfonyl]isatin | pH 7.5, 30°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000025 | - |
IC50: 2.5 nM | Homo sapiens | (S)-1-benzyl-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin | |
0.0000031 | - |
IC50: 3.1 nM | Homo sapiens | (S)-1-[(tert-butyloxycarbonyl)methyl]-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin | |
0.0000042 | - |
IC50: 4.2 nM | Homo sapiens | (S)-1-(4-pyridinylmethyl)-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonal]isatin | |
0.0000046 | - |
IC50: 4.6 nM | Homo sapiens | (S)-1-allyl-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin | |
0.0000052 | - |
IC50: 5.2 nM | Homo sapiens | (S)-1-(cyclohexylmethyl)-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonal]isatin | |
0.00003 | - |
IC50: 30 nM | Homo sapiens | (S)-1-methyl-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin | |
0.000031 | - |
IC50: 31 nM | Homo sapiens | (S)-5-[1-[2-(anilinomethyl)pyrrolidinyl]sulfonyl]isatin | |
0.000044 | - |
IC50: 44 nM | Homo sapiens | (S)-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin | |
0.000044 | - |
IC50: 44 nM | Homo sapiens | (S)-(+)-5-[1-[2-(thiophenoxymethyl)pyrrolidinyl]sulfonyl]isatin | |
0.00007 | - |
IC50: 70 nM | Homo sapiens | (S)-5-[1-[(2-tert-butoxycarbonyl)pyrrolidinyl]sulfonyl]isatin | |
0.00012 | - |
IC50: 120 nM | Homo sapiens | (S)-5-[1-(2-methoxymethyl)pyrrolidinylsulfonyl]isatin | |
0.00014 | - |
IC50: 140 nM | Homo sapiens | (S)-5-[1-[2-(phenylaminocarbonyl)pyrrolidinyl]sulfonyl]isatin | |
0.00017 | - |
IC50: 170 nM | Homo sapiens | (S)-1-(carboxymethyl)-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin | |
0.00017 | - |
IC50: 170 nM | Homo sapiens | (S)-5-[1-[(2-methoxycarbonyl)pyrrolidinyl]sulfonyl]isatin | |
0.00017 | - |
IC50: 170 nM | Homo sapiens | 5-[1-(azetidinyl)sulfonyl]isatin | |
0.00041 | - |
IC50: 410 nM | Homo sapiens | (S)-5-[1-[[2-(dimethylamino)carbonyl]pyrrolidinyl]sulfonyl]isatin | |
0.0019 | - |
IC50: 0.0019 mM | Homo sapiens | 5-[1-(hexamethyleneimino)sulfonyl]isatin | |
0.0022 | - |
IC50: 0.0022 mM | Homo sapiens | 5-[1-(piperidinyl)sulfonyl]isatin | |
0.0028 | - |
IC50: 0.0028 mM | Homo sapiens | 5-[1-(pyrrolidinyl)sulfonyl]isatin | |
0.0055 | - |
IC50: 0.0055 mM | Homo sapiens | (R)-5-[1-[2-(anilinomethyl)pyrrolidinyl]sulfonyl]isatin | |
0.018 | - |
IC50: 0.018 mM | Homo sapiens | (R)-5-[1-(2-methoxymethyl)pyrrolidinylsulfonyl]isatin |