Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | when protein kinase CK2 activity is low, procaspase-2 is dephosphorylated, dimerized, and activated in a PIDDosome-independent manner | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C320A | forms a dimer only when cell are treated with DRB | Homo sapiens |
S157A/C320A | nonphosphorylatable, dimerizes constitutively | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
protein kinase CK2 | phosphorylates procaspase-2 directly at serine-157. When protein kinase CK2 activity is low, procaspase-2 is dephosphorylated, dimerized, and activated in a PIDDosome-independent manner | Homo sapiens | |
Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-CH2F | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P42575 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HCE-4 cell | human esophageal cancer cell line | Homo sapiens | - |
HCE-7 cell | human esophageal cancer cell line | Homo sapiens | - |
HCT-116 cell | human colon cancer cell line | Homo sapiens | - |
LN-319 cell | human malignant glioma cell line | Homo sapiens | - |
SW-480 cell | human colon cancer cell line | Homo sapiens | - |
TE-2 cell | human esophageal cancer cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
procaspase-8 + H2O | processing occurs between the large and small subunits | Homo sapiens | processed procaspase-8 | p43/41 form | ? |
Subunits | Comment | Organism |
---|---|---|
dimer | active form, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
caspase-2 | - |
Homo sapiens |