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Literature summary for 3.4.22.49 extracted from

  • Kudo, N.R.; Anger, M.; Peters, A.H.; Stemmann, O.; Theussl, H.C.; Helmhart, W.; Kudo, H.; Heyting, C.; Nasmyth, K.
    Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I (2009), J. Cell Sci., 122, 2686-2698.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
the active (S1126A/T1346A) and the inactive (C1129S) separase mutants are coexpressed in HEK-293T cells with human securin Homo sapiens

Protein Variants

Protein Variants Comment Organism
C1129S inactive Homo sapiens
S1126A/T1346A active mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
securin
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Rec8 + H2O Rec8 is a meiosis-specific alpha-kleisin subunit of cohesion, phosphorylation by polo-like kinase 1 of either Rec8 or separase, or both, promotes Rec8 cleavage. Separase prefers to cleave at R454 Homo sapiens fragments of Rec8
-
 ?
Scc1 + H2O Scc1 is an alpha-kleisin subunit of cohesin Homo sapiens fragments of Scc1
-
 ?