Application | Comment | Organism |
---|---|---|
molecular biology | in Saccharomyces cerevisiae separase it is shown that separase is implicated in a second non-proteolytic pathway: separsae is essential for the activation of Cdc14 phosphatase and thus a broad programme of late mitotic events culminating in mitotic exit and cell division | Saccharomyces cerevisiae |
molecular biology | separse is not only required for chromosome segregation but also for meiotic exit | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | clear evidence for a non-proteolytic function of separase is provided: by separase gene deletion in mouse oocytes it is shown that separase null-oocytes are unable to either destroy chesin along chromosome arms or segregate homologous chromosomes and these oocytes are unable to complete cell division. Microinjection of wild-type separase mRNA in separase null-oocytes restores normal homologue disjunction and polar body extrusion | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
oocyte | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
separase | - |
Mus musculus |
separase | - |
Saccharomyces cerevisiae |